Overview
- Sportsbooks posted opening Week 12 lines, including Bills at Texans at Bills -3.5 with a total of 43.5 at DraftKings.
- Kansas City’s spread vs. Indianapolis reset to -3.5 from a -4.5 look‑ahead after the loss in Denver, and the total has dipped from as high as 50.5 to about 49.
- Early guidance points to betting San Francisco -6.5 now, with Brock Purdy back and the 49ers offense rebounding.
- The Buccaneers–Rams total opened near 49 and many books are at 49.5 with increasing Over juice, signaling a possible rise to 50.
- Bettors are urged to wait on Bills–Texans and on the Colts–Chiefs total, with C.J. Stroud’s concussion status and further market movement expected to influence prices.