Overview
- Saturday’s slate opens with Bills at Broncos at 4:30 p.m. ET on CBS/Paramount+ followed by 49ers at Seahawks at 8 p.m. ET on FOX, with two more divisional games Sunday on ESPN/ABC and NBC/Peacock.
- Denver enters rested with home field after a bye and an NFL‑best 68 sacks, while Buffalo quarterback Josh Allen practiced fully to close the week and carries no injury designation.
- Seattle lists quarterback Sam Darnold as questionable with an oblique injury, and San Francisco is without tight end George Kittle for the season, though left tackle Trent Williams carries no designation.
- On Sunday, New England hosts Houston with Texans wide receiver Nico Collins ruled out due to a concussion and Patriots cornerback Christian Gonzalez cleared to play; Chicago then hosts the Rams in the nightcap.
- Expert picks lean heavily toward Seattle over San Francisco, with injuries cited as a key factor in that forecast.