Overview
- The four matchups are set for Saturday and Sunday: Bills at Broncos at 4:30 p.m. ET and 49ers at Seahawks at 8 p.m. ET on Saturday, followed by Texans at Patriots at 3 p.m. ET and Rams at Bears at 6:30 p.m. ET on Sunday.
- Books list Denver, Seattle, New England and Los Angeles as favorites, with recent lines including Broncos -1 to -1.5, Seahawks -7, Patriots -3 and Rams -3.5.
- CBS Sports reports SportsLine has locked a six-leg longshot parlay generated from 10,000 simulations per game that it says could return $1 million on a $10 bet.
- One parlay leg backs the Over on an alternate 48.5 total in Seahawks–49ers based on a projection of roughly 50 combined points.
- SportsLine’s model identifies Chicago as a strong play to cover +3.5 against the Rams, while FanSided ranks Bills at Broncos as the most likely upset behind confidence in Josh Allen and notes injuries such as George Kittle being out for San Francisco.