Overview
- Saturday features Bills at Broncos at 4:30 p.m. ET and 49ers at Seahawks at 8 p.m. ET, followed Sunday by Texans at Patriots at 3 p.m. ET and Rams at Bears at 6:30 p.m. ET.
- BetMGM lists spreads of Denver -1.5 vs. Buffalo, Seattle -7 vs. San Francisco, New England -3 vs. Houston, and Los Angeles -3.5 at Chicago, with totals of 46, 45, 40.5 and 48.5 respectively.
- CBS Sports highlights a SportsLine six-leg longshot parlay built from 10,000 simulations, including a pick backing an alternate Over 48.5 in Seahawks–49ers based on a 50-point projection.
- SportsLine’s model identifies Chicago +3.5 versus the Rams as a top play and shows the game’s Over cashing in well over half of simulations.
- FanSided ranks Bills at Broncos as the most likely upset opportunity, while USA TODAY notes Seattle enters as the week’s biggest favorite after holding San Francisco to 10 points per game in two meetings.