Overview

• The Mount Sinai–led Navigation Guide review assessed 46 studies covering more than 100,000 participants and found consistent associations with autism and ADHD.
• Authors reported that higher-quality studies were more likely to detect links between prenatal exposure and later neurodevelopmental diagnoses.
• The paper outlines plausible biological pathways, including placental transfer, oxidative stress, hormonal disruption, and epigenetic effects.
• Evidence remains mixed, with a large 2024 Swedish cohort reporting no association and prior legal and regulatory reviews judging the data insufficient for definitive conclusions.
• Clinicians and public bodies continue to advise using acetaminophen in pregnancy at the lowest effective dose for the shortest time, and patients are urged not to stop medication without consulting a doctor.