New Study Reveals How Azole Antifungals Trigger Self-Destruction in Fungal Pathogens
University of Exeter researchers uncover cellular mechanisms behind the effectiveness of azoles, offering potential advancements in combating fungal resistance.
- Azoles deplete ergosterol in fungal cells, leading to increased mitochondrial activity and toxic by-products.
- These by-products initiate apoptosis and macroautophagy, causing the pathogen cells to self-destruct.
- The study challenges previous beliefs about how azoles kill fungi, showing a more complex process.
- Findings could improve strategies for protecting crops and human health against fungal infections.
- Understanding these mechanisms may help address the growing issue of azole resistance in pathogens.
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