New Study Links Sucralose to Increased Hunger and Altered Brain Activity

Research from the University of Southern California finds that sucralose heightens hunger by disrupting appetite-regulating brain functions, with potential long-term health implications.

• Sucralose, a common artificial sweetener, increases activity in the hypothalamus, the brain region responsible for regulating appetite and body weight.
• Unlike sugar, sucralose does not trigger fullness-related hormones such as insulin and GLP-1, leading to increased hunger, particularly in individuals with obesity.
• The study found sex-based differences, with female participants showing greater changes in brain activity compared to males after consuming sucralose.
• Researchers observed that sucralose alters brain connectivity related to motivation, sensory processing, and decision-making, potentially influencing cravings and eating behaviors.
• Further studies are underway to assess the long-term effects of sucralose, especially on children and adolescents, amid concerns about its broader health risks.

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