Overview

• The NIH-NINDS spearheaded the creation of the CBI-M framework, replacing the 51-year-old Glasgow Coma Scale to address its diagnostic limitations.
• CBI-M incorporates four pillars: clinical evaluation, blood biomarkers, advanced neuroimaging, and contextual modifiers to provide a comprehensive assessment of TBIs.
• Biomarkers enable differentiation between TBIs and minor head injuries, reducing unnecessary CT scans and improving clinical trial enrollment accuracy.
• The framework aims to enhance treatment matching, prevent chronic symptoms in mild cases, and avoid premature life-support decisions in severe cases.
• Currently being piloted in U.S. trauma centers, the framework will undergo refinement and validation before full adoption.