Overview

• A systematic review in JAMA Psychiatry of 50 randomized trials covering about 18,000 patients found most people stopping antidepressants reported only one extra symptom on average—predominantly dizziness—and no severe withdrawal.
• The analysis detected no increase in depression or mood relapse following discontinuation, indicating that renewed low mood likely reflects underlying illness recurrence.
• Experts from the University of East London have criticized the study for its reliance on short follow-up periods and trials funded by drug manufacturers, warning it may understate real-world withdrawal.
• Lead authors and professional bodies have called for updating clinical guidelines to reflect the low incidence of withdrawal and to promote cautious tapering and patient support.
• The review identifies a small subgroup of long-term antidepressant users who may still experience more severe discontinuation effects, prompting further pharmacological investigation.