Overview

• Global liver cancer cases are projected to rise from 870,000 in 2022 to 1.52 million by 2050, with deaths increasing from 760,000 to 1.37 million.
• The proportion of cases linked to hepatitis B and C is expected to decline modestly while alcohol-related and MASLD-associated cases rise to about 21% and 11%, respectively, by 2050.
• About 60% of liver cancer cases stem from modifiable risk factors such as viral hepatitis, alcohol use and obesity-related liver disease.
• The Lancet Commission recommends expanding hepatitis B vaccination programs, implementing alcohol pricing reforms and obesity-targeted public health measures, and strengthening early detection.
• If countries achieve a 2–5% annual reduction in incidence, they could prevent 9–17 million new cases and save 8–15 million lives by mid-century.