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14h ago

New JAMA Study Recasts Global COVID-19 Vaccine Benefit at 2.5 Million Lives Saved

Authors argue that pandemic vaccination efforts should be refocused on older adults based on risk-benefit evidence.

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Overview

  • The JAMA Health Forum study finds that COVID-19 vaccination from 2020 to 2024 prevented about 2.5 million deaths worldwide.
  • Researchers estimate that inoculations saved 14.8 million life-years, equal to one life-year per 900 vaccine doses administered.
  • Over 90 percent of lives saved occurred in people aged 60 and above, while under-20s had just 299 deaths averted and those aged 20–30 accounted for 1,808 lives saved.
  • Analysis shows that 5,400 vaccine doses were needed to prevent one death overall, rising to 100,000 doses for individuals under 30.
  • Lead author John Ioannidis and colleagues criticize blanket vaccination mandates as lacking risk-based precision and recommend prioritizing high-risk populations in future rollouts.