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New JAMA Study Finds Vitamin K Refusal at Birth Has Risen 77% Since 2017

Experts caution that skipping the shot sharply increases the risk of preventable infant bleeding.

Overview

  • Children’s Hospital of Philadelphia researchers analyzed Epic Cosmos records for more than five million newborns across 403 U.S. hospitals from 2017 to 2024.
  • The share of infants not receiving intramuscular vitamin K increased from 2.92% to 5.18%, representing roughly 200,000 babies who missed the shot.
  • The uptick began around 2019 and accelerated during and after the pandemic, with the highest refusal rates reported among non-Hispanic White infants.
  • According to the CDC, babies who forgo the shot are about 80 times more likely to experience severe vitamin K deficiency bleeding, including intracranial hemorrhage.
  • Authors and outside experts point to misinformation and confusion with vaccines, stress that oral vitamin K is less reliable, and note the study did not document a national rise in bleeding cases.