New Insights Uncover How Herpes Virus Evades Antiviral Drugs
Harvard researchers reveal the role of protein movements in HSV drug resistance, opening paths for improved treatments.
- Harvard study uses cryo-EM to visualize HSV polymerase enzyme dynamics.
- Findings show drug resistance mutations occur far from drug-binding sites.
- HSV polymerase's flexibility complicates effective drug binding.
- Research suggests targeting enzyme movements could counter resistance.
- Insights may aid development of treatments for other viral infections.