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New Insights Uncover How Herpes Virus Evades Antiviral Drugs

Harvard researchers reveal the role of protein movements in HSV drug resistance, opening paths for improved treatments.

  • Harvard study uses cryo-EM to visualize HSV polymerase enzyme dynamics.
  • Findings show drug resistance mutations occur far from drug-binding sites.
  • HSV polymerase's flexibility complicates effective drug binding.
  • Research suggests targeting enzyme movements could counter resistance.
  • Insights may aid development of treatments for other viral infections.
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