Overview

• The University of Geneva team found IL-38 forms condensates in keratinocytes, increasing near the skin's surface where oxygen levels are higher.
• IL-38's behavior in keratinocytes suggests a link to programmed cell death, crucial for epidermal renewal.
• Oxidative stress, caused by oxygen exposure, triggers IL-38 condensation, indicating keratinocytes' readiness for cell death.
• This discovery could lead to better understanding of skin diseases like psoriasis and atopic dermatitis.
• A new experimental model is being developed to study oxidative stress effects without relying on animal models.