New Hormone Found in Breastfeeding Women Could Revolutionize Osteoporosis Treatment

Researchers identify CCN3, a brain hormone that strengthens bones during lactation, with potential applications for bone healing and osteoporosis therapy.

• CCN3, also called Maternal Brain Hormone (MBH), was discovered in lactating mice and shown to increase bone density and strength.
• The hormone helps maintain bone health in breastfeeding women despite low estrogen levels, which typically weaken bones.
• Experiments demonstrated that CCN3 can significantly enhance bone mass in both young and old mice, including those lacking estrogen.
• A hydrogel patch with CCN3 applied to bone fractures in elderly mice promoted rapid and robust healing.
• Future research will explore CCN3's potential in treating various bone conditions and its mechanisms in humans.

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