New Genetic Tool Shows Promise in Treating High Cholesterol
University of Zurich researchers enhance TnpB protein for efficient DNA editing, achieving significant results in mouse models.
- Scientists have engineered the TnpB protein, derived from Deinococcus radiodurans, to effectively edit genes associated with high cholesterol.
- Using AI models, the team achieved up to 75.3% editing efficiency in mouse livers and 65.9% in mouse brains.
- This new method addresses the size limitations of the CRISPR-Cas system, enabling better delivery to target cells.
- Experiments demonstrated an 80% reduction in cholesterol levels in mice with genetically induced hypercholesterolemia.
- The research aims to develop similar gene editing strategies for treating inherited conditions in humans.
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