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9mo ago

New Electroporation Technique Enhances Brain Tumor Treatment

B-SWE method disrupts blood-brain barrier more effectively, allowing better drug delivery with minimal tissue damage.

3d render of a medical background with male figure with tumours in brain highlighted
Research indicates that the conventional square waveforms show good blood-brain barrier disruption, but this study finds even better blood-brain barrier disruption with B-SWE. Credit: Neuroscience News

Overview

  • Researchers from Georgia Tech and Virginia Tech developed the burst sine wave electroporation (B-SWE) technique.
  • B-SWE outperforms the conventional H-FIRE method in disrupting the blood-brain barrier.
  • The new method allows more cancer-fighting drugs to reach brain tumors while minimizing damage to healthy tissue.
  • Adjustments to B-SWE reduced neuromuscular contractions, a significant side effect.
  • Future studies will compare B-SWE and H-FIRE using animal models of brain cancer.