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New DNA Study Finds Paratyphoid and Relapsing Fever in Napoleon’s 1812 Dead

Untargeted sequencing of 13 teeth from a Vilnius mass grave uncovered pathogen DNA, offering evidence of co-circulating infections during the retreat.

Overview

  • Institut Pasteur researchers report in Current Biology that four of 13 soldiers carried Salmonella enterica Paratyphi C and two carried Borrelia recurrentis.
  • The teeth came from a mass grave near Vilnius discovered in 2001 that holds nearly 3,000 individuals identified as members of the Grande Armée.
  • The team used next-generation, untargeted ancient-DNA screening of dental pulp followed by phylogenetic placement to authenticate pathogen fragments.
  • Earlier tests in 2006 on the same assemblage had detected typhus and Bartonella quintana, expanding the picture of multiple infections during the retreat.
  • The authors caution that the small sample and nature of DNA signals do not establish cause of death, noting cold, hunger, exhaustion and disease likely acted together.