Overview

• Researchers from Karolinska Institutet report in The BMJ that CORE predicts the 10-year risk of cirrhosis or liver cancer using age, sex, AST, ALT and GGT.
• The model was developed on health-check data from more than 480,000 people in Stockholm with up to 30 years of follow-up, then tested in cohorts from Finland and the UK.
• CORE showed high discrimination of about 88% and outperformed the commonly used FIB-4 score in the evaluated populations.
• A public web-based calculator is available now, with the aim of enabling risk estimation in primary care settings.
• Study authors urge further validation in high-risk groups such as people with type 2 diabetes or obesity, plus integration into electronic records, noting liver disease is often silent early and causes over 11,000 deaths a year in the UK.