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New Cheek Swab Test Predicts Mortality Risk

The CheekAge test, developed by Tally Health, uses DNA methylation markers to estimate lifespan from cheek cells.

Overview

  • CheekAge, an epigenetic clock, measures biological aging through a simple cheek swab.
  • The test was validated using blood samples from over 1,500 elderly participants in the Lothian Birth Cohorts study.
  • For each standard deviation increase in CheekAge versus chronological age, the risk of death rose by 21%.
  • Key DNA markers, such as ALPK2 and PDZRN4, were identified as significant predictors of mortality.
  • CheekAge's performance in predicting mortality outpaced several established blood-based epigenetic clocks.