Overview

• The study identifies two potent antimalarial compounds that block Plasmodium parasite development within mosquitoes without killing them, avoiding resistance issues.
• When incorporated into bed-net prototypes, the compounds eradicated 100% of parasites at low doses and retained full efficacy for at least one year.
• These nets remain effective even when mosquitoes contact them up to four days before becoming infected, significantly reducing transmission potential.
• The compounds were synthesized inexpensively, enabling integration into existing bed-net distribution systems at competitive costs.
• The findings, published in Nature on May 21, 2025, mark a major step toward scalable field trials and regulatory approval for this innovative malaria control strategy.