Overview

• Oligodendrocytes, not just neurons, produce amyloid beta, a protein linked to Alzheimer's disease.
• Suppressing amyloid beta in oligodendrocytes improved brain pathology and neuronal function in mice.
• The findings challenge the belief that neurons are the primary source of toxic amyloid beta.
• Targeting oligodendrocyte-derived amyloid beta could become a novel treatment strategy for Alzheimer's.
• The study highlights the importance of re-evaluating current Alzheimer's treatment approaches.