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New Algorithm Revolutionizes Enzyme Engineering

Researchers develop a method that uses evolutionary history to enhance enzyme performance, with broad industrial applications.

  • Scientists created an algorithm to introduce targeted mutations in enzymes, improving their activity and stability.
  • The method focuses on beta-lactamase, an enzyme crucial for antibiotic resistance.
  • Up to 84 mutations were successfully introduced, significantly enhancing enzyme functionality.
  • The engineered enzymes retained their 3D structure despite extensive sequence changes.
  • Potential applications include food production, plastic degradation, and healthcare.
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