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NEJM Study Links Pediatric Medical Imaging Radiation to Higher Blood Cancer Risk

An analysis of 3.7 million children found risk rises with cumulative radiation dose.

Overview

  • CT scans, especially head CTs, carried the greatest risk, with one or two head CTs linked to a 1.8-fold increase and higher cumulative scans up to 3.5-fold, and about a quarter of subsequent cases among head‑CT patients attributed to radiation.
  • Researchers estimate roughly 10% of hematologic cancers in the cohort—about 3,000 cases—were attributable to radiation from diagnostic imaging.
  • Across six U.S. health systems and Ontario, 2,961 hematologic malignancies were identified over approximately a decade of follow‑up.
  • Children exposed to about 30 milligrays had a 76% higher risk of hematologic cancer compared with those with no documented exposure.
  • Authors urge limiting nonessential imaging, using the lowest feasible radiation doses, and favoring ultrasound or MRI when appropriate, noting radiographs deliver far lower doses and were tied to only a small fraction of cases.