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Neil Patrick Harris to Voice Deadpool in Upcoming VR Game

Ryan Reynolds responded with a playful Doogie Howser parody after the trailer premiered at Summer Game Fest 2025

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deadpool at a dinner party in Deadpool & Wolverine
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Overview

  • Neil Patrick Harris has been cast as the voice of Deadpool in Marvel’s Deadpool VR for Meta Quest 3 and Quest 3S, replacing Ryan Reynolds.
  • The game’s debut trailer showcased first-person combat, signature weapons and the brand’s irreverent humor.
  • Reynolds, whose film tenure as Deadpool dates to 2009, released a spoof video channeling Doogie Howser to mock Harris for “stealing” his role.
  • In the parody, Robyn Lively appears in a tongue-in-cheek cameo as Reynolds alternately berates and praises Harris’s acting.
  • Marvel’s Deadpool VR is scheduled to launch later in 2025, promising a violent, expletive-ridden adventure for players.