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Neglect Alone Linked to White-Matter Changes in Three Brain Pathways in Children

Researchers say the pathway-specific differences could guide earlier identification of neglected children pending validation.

Overview

  • Using diffusion tensor imaging, the University of Fukui team compared 21 neglected children with 106 typically developing peers to isolate the effects of neglect without other maltreatment.
  • Abnormalities localized to the right corticospinal tract, right superior longitudinal fasciculus, and left cingulum, with increased axial diffusivity indicating altered white-matter microstructure.
  • The observed pathway changes correlated with conduct problems and behavioral difficulties within the neglected group.
  • The peer-reviewed findings, published July 26 in Scientific Reports, position these neuroimaging differences as potential objective indicators for screening and intervention design.
  • Researchers emphasize limits of the cross-sectional, modest sample and call for replication, larger and longitudinal cohorts, and evaluation before any clinical or policy adoption.