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Murder Trial Begins for Colorado Dentist Accused of Poisoning Wife’s Protein Shakes

Jurors have been seated for opening statements outlining dueling accounts of toxicology evidence ahead of forthcoming witness testimony

FILE - This undated booking photo provided by the Aurora, Colorado Police Department shows James Craig.
James Craig talks with his family from his seat before opening arguments in his murder trial, as he is accused of killing his wife, at the Arapahoe District Court, Tuesday, July 15, 2025, in Centennial, Colo. (Stephen Swofford via Denver Gazette, Pool)
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FILE - Law enforcement personnel provide security for a court appearance at the Arapahoe County Courthouse, July 23, 2012, in Centennial, Colo. (AP Photo/Alex Brandon, File)

Overview

  • Opening statements kicked off the trial on July 15, with a 15-member jury seated in Arapahoe County District Court.
  • Prosecutors contend James Craig deliberately laced his wife Angela’s protein shakes with arsenic, tetrahydrozoline and cyanide to mask a murder as illness or suicide.
  • Key evidence includes Craig’s digital searches for undetectable poisons, online orders of arsenic and cyanide, home surveillance footage and the coroner’s finding of acute cyanide and tetrahydrozoline poisoning with subacute arsenic.
  • Craig also faces charges of soliciting a fellow inmate to kill the lead investigator and of plotting to fabricate false testimony.
  • Defense attorneys have disputed the forensic conclusions, challenged the credibility of jailhouse informants and allege investigative tunnel vision as testimony from experts unfolds.