Overview

• A national double-blind randomized trial across six Canadian pediatric hospitals enrolled over 1,000 children aged six months to 18 years to assess home ondansetron use after ED discharge.
• Children who received a small multidose supply at home experienced significantly lower rates of moderate-to-severe vomiting recurrence.
• The New England Journal of Medicine published the study on July 16, and TREKK has incorporated the findings into its national emergency discharge guidelines.
• Pediatric Emergency Research Canada network co-founders highlighted the trial as a model for cross-country collaboration in pediatric emergency medicine.
• Acute gastroenteritis drives more than two million pediatric ED visits and over 50,000 hospitalizations annually in North America, emphasizing the impact of improved outpatient care.