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Multicancer Blood Test Detects Tumors Three Years Before Diagnosis

This discovery could transform cancer screening by spotting tumor DNA in blood years before clinical signs emerge

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Overview

  • The Johns Hopkins team published their findings in Cancer Discovery after testing 52 plasma samples from an NIH cardiovascular study
  • The multicancer early detection (MCED) assay correctly flagged eight participants who received cancer diagnoses within six months of their blood draw
  • Further analysis of earlier stored samples from six individuals revealed tumor-derived mutations up to 3.5 years before their clinical diagnosis
  • Although some MCED tests are offered as Laboratory Developed Tests, none have full FDA approval and researchers call for larger trials to confirm accuracy
  • Scientists stress that establishing clear clinical follow-up protocols will be vital to turn early detection into better treatment outcomes