Overview

• Published in Cell Reports Medicine, the analysis integrated genome, epigenetic, metabolomic, immune and microbiome data from samples collected before her 2024 death.
• Compared with 75 Iberian women, her cells appeared biologically younger, with youthful immune and gut profiles plus exceptionally favorable lipid measures.
• The team reported rare protective variants linked to immune resilience, metabolic efficiency and neuroprotection.
• Lead author Manel Esteller told CNN longevity in her case may be roughly half genetics and half daily habits, which included a Mediterranean diet, regular walking, and no smoking or alcohol, with frequent yogurt.
• Authors and outside experts emphasize that the results are not generalizable from one person and must be tested in larger, longitudinal cohorts.