Overview
- In diet-induced obese mice, resistance exercise produced larger gains in glucose tolerance and insulin sensitivity than voluntary running.
- Both modalities reduced subcutaneous and visceral fat, with greater reductions observed in the resistance-trained group.
- The team created a progressive mouse weightlifting model that required squat-like lifts of a weighted lid to access food over eight weeks.
- Improvements in the resistance group were linked to enhanced insulin signaling in skeletal muscle that could not be explained solely by muscle mass.
- Study authors advise combining resistance and endurance training, and independent experts emphasize sustainable choices and the need for human validation.