Mouse Aging Proteomic Atlas Illuminates Protein Changes Over Time

A new comprehensive database reveals molecular insights into age-related protein changes across major tissues in mice.

Researchers at Osaka Metropolitan University have created the Mouse Aging Proteomic Atlas, a detailed database mapping protein changes in aging mice.
The study analyzed proteomes and transcriptomes from tissues such as the brain, heart, and skin in mice aged 6 to 30 months.
Key findings highlight proteins in the extracellular matrix that increase with age, offering potential targets for age-related disease prevention.
This research enhances understanding of aging at the molecular level, revealing post-transcriptional dysregulation as a significant factor.
The atlas serves as a valuable resource for future studies aiming to mitigate age-related conditions through targeted interventions.