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Mount Sinai Study Introduces NutriSighT to Predict Underfeeding in Ventilated ICU Patients

Using routine ICU data with four-hour updates, the interpretable system now advances to prospective trials for clinical impact.

Overview

  • The peer-reviewed study was published December 17, 2025, in Nature Communications.
  • Underfeeding was frequent early in ICU care, affecting about 41–53% of patients by day three and 25–35% by day seven.
  • NutriSighT forecasts which patients may be underfed on days three to seven of ventilation hours in advance and refreshes its risk estimates every four hours.
  • The model highlights routine drivers of risk, including blood pressure, sodium levels, and sedation exposure, to support clinician interpretation.
  • Investigators describe the tool as decision support rather than a replacement for clinicians, with plans for multi-site prospective trials and careful EHR integration.