Overview

• Researchers isolated three monoclonal antibodies from a recovered patient that blocked viral spread in vitro and prevented death in rodent models.
• The antibodies target the A35 protein and bind a highly conserved epitope shared across orthopoxviruses and the broader poxvirus family.
• The Cell study reports the first crystal structure of a human antibody bound to an mpox protein, revealing a specific viral vulnerability.
• Human serology showed frequent A35‑focused responses, with higher levels associated with milder illness and no hospitalization.
• With no approved mpox treatments and recent trials failing to show efficacy, the team is advancing these candidates toward preclinical evaluations before human trials.