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Molecular Testing Revolutionizes Heart Transplant Care with Non-Invasive Monitoring

Cell-free DNA testing now replaces 95% of biopsies, personalizes immunosuppression, and enables remote patient surveillance for improved outcomes.

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Overview

  • Cell-free DNA (cfDNA) testing, introduced as early as one month post-transplant, has reduced the need for invasive biopsies by 95% during the first few years after surgery.
  • The technology identifies donor heart injury or rejection risk through small DNA fragments in the bloodstream, providing earlier and more precise detection.
  • Molecular testing allows for personalized immunosuppressive therapy, reducing medication dosages for low-risk patients and minimizing side effects such as infections, kidney impairment, and cancer risk.
  • Remote monitoring enabled by molecular diagnostics improves patient access to care, reducing the need for frequent visits to transplant centers and enhancing quality of life.
  • Ongoing research explores expanding molecular assays to include gut microbiome profiling, early cancer detection, viral screening, and gene expression analysis to further optimize post-transplant care.