Overview

• The FAME 2.0 study tracked 200 healthy men aged 18–85 from 2014 to 2020 and maintained 117 participants free of diabetes, heart disease and cancer.
• Researchers reported that hormone levels and standard semen parameters remained largely within normal ranges despite participants’ aging.
• Men whose HbA1c levels rose slightly—yet stayed below the 6.5% diabetes cutoff—experienced measurable drops in sperm motility and erectile performance.
• Testosterone measures did not directly affect erectile function but were associated with variations in participants’ self-reported libido.
• Study authors propose that targeted lifestyle and metabolic interventions could help preserve men’s sexual and reproductive health as they age.