Overview
- The season begins with a standalone Opening Night at Oracle Park as the Giants host the Yankees on March 25, followed by a 14-game Opening Day slate on March 26, the earliest traditional opening on record.
- The 96th All-Star Game is set for July 14 at Citizens Bank Park in Philadelphia, and the regular season is scheduled to conclude on September 27.
- MLB approved the Athletics to stage six regular-season home games at Las Vegas Ballpark from June 8–14 against the Brewers and Rockies, with the club otherwise based at West Sacramento as construction advances on its future Strip stadium.
- The schedule features a Rivalry Weekend from May 15–17 and places the Yankees–Mets series at Yankee Stadium on September 11–13 to mark the 25th anniversary of 9/11.
- Built-in off days accommodate World Cup events at shared sites in Arlington, Kansas City and Seattle, while balanced scheduling continues and potential special events in Dyersville and Mexico City remain to be finalized.