Overview

• Intestinal stem cells regenerate more effectively after fasting when refeeding begins.
• The mTOR pathway is activated during refeeding, promoting cell growth and protein synthesis.
• Increased stem cell activity during refeeding can lead to early-stage intestinal tumors in mice.
• The study highlights the need for cautious dietary strategies to balance regeneration and cancer risk.
• Further research is required to understand the implications for human health.