MIT Study Identifies Key Factors in Alzheimer's Vulnerability and Cognitive Resilience

Research uncovers how specific brain cells and circuits are affected by Alzheimer's and highlights potential protective mechanisms.

Gene expression in over 1.3 million cells across six brain regions was analyzed.
Reelin-producing neurons are linked to cognitive resilience despite Alzheimer's pathology.
Choline metabolism in astrocytes is associated with sustained cognition.
Findings suggest new therapeutic targets to maintain cognitive function.
The study provides a detailed atlas of cellular changes in Alzheimer's.