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4w ago

MIT Researchers Unveil Injectable Microcrystal System for Long-Term Drug Delivery

The system, tested in preclinical studies, offers potential for months-long drug release and is being optimized for human trials.

image: ©andreswd | iStock
MIT engineers have devised a new way to deliver certain drugs in higher doses with less pain, by injecting them as a suspension of tiny crystals. Once under the skin, the crystals assemble into a drug “depot” that could last for months or years, eliminating the need for frequent drug injections.
Image for representation purpose only.
Whether you have a deep-seated fear of needles (Trypanophobia) or simply aren't a fan of jabs, this drug delivery approach is good news

Overview

  • MIT scientists have developed a novel injectable drug delivery system using self-assembling microcrystals that form a depot under the skin for controlled, long-term drug release.
  • The system, tested in rats, demonstrated steady drug release over three months, with 85% of the drug remaining, indicating potential for extended durations of over a year.
  • Designed to improve accessibility, the method uses biocompatible solvents and small needles, enabling self-administration and reducing discomfort.
  • Initially aimed at providing long-lasting contraceptives, the system also shows promise for treating HIV, tuberculosis, neuropsychiatric disorders, and chronic pain.
  • Researchers are advancing preclinical studies to optimize the technology for human trials, which are anticipated within three to five years.