MIT Researchers Unveil Injectable Microcrystal System for Long-Term Drug Delivery

The system, tested in preclinical studies, offers potential for months-long drug release and is being optimized for human trials.

MIT scientists have developed a novel injectable drug delivery system using self-assembling microcrystals that form a depot under the skin for controlled, long-term drug release.
The system, tested in rats, demonstrated steady drug release over three months, with 85% of the drug remaining, indicating potential for extended durations of over a year.
Designed to improve accessibility, the method uses biocompatible solvents and small needles, enabling self-administration and reducing discomfort.
Initially aimed at providing long-lasting contraceptives, the system also shows promise for treating HIV, tuberculosis, neuropsychiatric disorders, and chronic pain.
Researchers are advancing preclinical studies to optimize the technology for human trials, which are anticipated within three to five years.