Overview

• A four-year study of 337 middle-aged adults in Catalonia links increased physical activity to reduced beta-amyloid accumulation, a key marker of Alzheimer’s disease.
• Participants who met or moved closer to WHO exercise guidelines exhibited greater cortical thickness in brain regions essential for memory and cognition.
• The research highlights dose-dependent benefits, showing that even incremental increases in physical activity improve brain health and reduce Alzheimer’s pathology.
• Experts emphasize midlife as a strategic intervention period, particularly for individuals with a family history of Alzheimer’s disease.
• The findings reinforce the need for public health strategies promoting physical activity to combat the global Alzheimer’s burden, attributed 13% to physical inactivity.