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Mice Perceive Artificial Limbs as Their Own in Rodent Rubber-Hand Illusion

The CNRS-led study published June 5 in PLOS Biology triggers embodiment responses in head-fixed mice by synchronizing tactile stimulation with artificial limb visuals.

The rubber-hand illusion was translated to the mouse model. Just like in humans, embodiment in mice can be achieved by brushing the real forelimb of the mouse and the artificial limb (yellow) in synchrony to generate matching visual and touch percepts.
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Overview

  • Researchers adapted the human rubber-hand illusion for mice by brushing a hidden real forelimb and a visible 3D-printed replica in precise synchrony.
  • Mice exposed to synchronous strokes maintained prolonged gaze on a threatening object near the artificial limb, signaling a sense of ownership.
  • Behavioral responses were stronger when the artificial limb resembled a real forelimb rather than a neutral object.
  • High-speed videography of pupil movements provided an objective measure to distinguish synchronous from asynchronous embodiment conditions.
  • This murine model offers a new platform to dissect neural circuits of embodiment and to refine strategies for prosthetic limb integration.