Overview

• A study in Aging Cell reviewed 167 lifespan experiments across eight vertebrate species and found rapamycin extends life nearly as effectively as calorie restriction.
• Dietary restriction delivered consistent lifespan gains in all species studied, whereas metformin showed no clear longevity benefit.
• High doses of rapamycin carry immunosuppressive risks, driving investigations into lower, intermittent dosing regimens.
• Early human trial data suggest that low-dose rapamycin is relatively safe in healthy older adults.
• Ongoing research aims to refine dosing strategies to balance life-extension effects with minimal side effects before larger clinical trials.