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5d ago

Meta-Analysis Links Atypical Handedness to Early-Onset Language-Related Disorders

New research highlights shared neurodevelopmental processes between handedness and conditions like dyslexia, autism, and schizophrenia, while ruling out connections to later-onset disorders like depression.

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(Photo by Olga Donchuk on Shutterstock)
The research team re-evaluated existing meta-analyses from a new perspective. Credit: Neuroscience News

Overview

  • An international research team published a meta-analysis in *Psychological Bulletin* on May 2, 2025, confirming a strong link between left- and mixed-handedness and early-onset, language-related disorders.
  • The study found that conditions such as dyslexia, autism spectrum disorder, and schizophrenia are significantly associated with non-right-handedness, reflecting shared early brain development processes.
  • No correlation was observed between atypical handedness and later-onset conditions like depression, suggesting the link is specific to disorders emerging early in life.
  • Researchers propose that handedness could serve as a behavioral biomarker for altered neurodevelopment, offering potential for earlier identification of at-risk individuals.
  • This meta-analysis resolves inconsistencies in prior research, emphasizing the role of brain lateralization in the development of language and motor functions.