Overview

• The review of 11 randomized trials covering nearly 2,500 participants shows weight regain begins around eight weeks after treatment cessation.
• Rebound weight gain continues for approximately 20 weeks before leveling off by about 26 weeks post-discontinuation.
• Patients on GLP-1 receptor agonists experienced the largest rebound, with tirzepatide users regaining almost half of their lost weight after switching to placebo.
• Even 52 weeks after stopping medication, participants remained below their baseline weight but had recovered a substantial portion of initial weight loss.
• Rising NHS prescriptions for weight-loss injections highlight widespread dependence and underscore calls for sustained medication use alongside lifestyle support.