Overview
- The PREDIMED-Plus randomized clinical trial followed 4,746 adults for six years and found a 31% lower incidence of type 2 diabetes in the intervention group versus a control group on a standard Mediterranean diet.
- Participants were ages 55 to 75, overweight or obese, had metabolic syndrome, and were free of diabetes at baseline.
- The intervention paired a Mediterranean eating pattern with about 600 fewer calories per day, moderate physical activity such as brisk walking and strength/balance work, and professional weight-loss support.
- Researchers reported modest absolute benefits—about three fewer cases per 100 people over the study period—alongside greater average reductions in weight (3.3 kg) and waist circumference (3.6 cm) than in controls.
- Findings, published in Annals of Internal Medicine, come from Europe’s largest nutrition and lifestyle randomized trial and involved sustained adherence supported by frequent counseling sessions.