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Measles Resurgence Threatens U.S. With Endemic Status Within Two Decades

A Stanford-led study warns declining vaccination rates could lead to millions of cases, hospitalizations, and deaths over 25 years.

Overview

  • The U.S. has reported over 800 measles cases across 27 states in 2025, including 624 cases and two deaths in a Texas-centered outbreak.
  • Childhood MMR vaccination rates have dropped to 93%, below the 95% threshold needed to maintain herd immunity and prevent outbreaks.
  • A new study projects measles could become endemic in the U.S. within 20 years, with 851,300 cases, 170,200 hospitalizations, and 2,550 deaths over 25 years at current vaccination levels.
  • If MMR vaccination rates decline by 10%, the U.S. could see 11.1 million measles cases over the next 25 years; a 50% drop could result in 51.2 million cases and 159,200 deaths.
  • Misinformation, including claims promoted by HHS Secretary Robert F. Kennedy Jr., continues to erode public trust in vaccines, complicating efforts to reverse the trend.