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McCaffrey Powers 49ers Past Panthers 20-9 as Purdy Throws Three First-Half Interceptions

The victory kept San Francisco in wild-card position in a tightening NFC race.

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Jauan Jennings (L) is separated from Tre'von Moehrig (R) after the game.
SANTA CLARA, CALIFORNIA - NOVEMBER 24: Christian McCaffrey #23 of the San Francisco 49ers runs into the end zone for a touchdown in the third quarter of the game against the Carolina Panthers at Levi's Stadium on November 24, 2025 in Santa Clara, California. (Photo by Thien-An Truong/Getty Images)
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Overview

  • San Francisco improved to 8-4 and moved into the NFC’s final wild-card spot, while Carolina fell to 6-6 and missed a chance to take the NFC South lead.
  • Brock Purdy threw three first-half interceptions and has multiple-pick games in three of his four starts this season, renewing ball-security concerns.
  • Christian McCaffrey totaled 31 touches for 142 scrimmage yards and a touchdown against his former team, anchoring the 49ers’ offense.
  • The 49ers’ defense limited the damage from turnovers, with Ji’Ayir Brown intercepting Bryce Young twice as Carolina finished 1-for-7 on third down with 161 net passing yards.
  • Postgame footage on ESPN showed Panthers safety Tre’von Moehrig striking Jauan Jennings below the belt before a scuffle, and the incident was reported to be under league review without an official NFL ruling announced.