Maternal Alzheimer's History Linked to Higher Amyloid Levels in Offspring

Study finds distinct parental influences on Alzheimer's risk, with maternal history more strongly associated with amyloid buildup.

Research analyzed 4,400 cognitively unimpaired adults aged 65–85.
Maternal history of Alzheimer's linked to increased amyloid levels regardless of symptom onset age.
Paternal history only significant if Alzheimer's symptoms appeared early.
Amyloid buildup was measured using PET scans in a large clinical trial.
Findings suggest maternal inheritance may be crucial for identifying at-risk individuals.