Overview
- Surgeons removed Tim Andrews’s porcine kidney on October 23 after declining function; he has resumed dialysis and remains on the human transplant waiting list.
- The eGenesis-supplied organ came from a CRISPR-edited pig with 69 genetic changes intended to reduce rejection and infectious risk.
- Mass General says it expects to perform another pig-to-human kidney transplant later in 2025, and a second recipient who received a pig kidney in June continues to fare well.
- Mass General and eGenesis previously reported FDA clearance to start the first multi-site clinical trial of porcine-derived kidneys, potentially enrolling more than 30 patients nationwide.
- Prior U.S. recipients experienced graft removals or early deaths, highlighting both incremental gains and unresolved risks as xenotransplantation transitions to controlled studies.